foreign body granuloma

 The foreign body granuloma is a response of biological tissue to any foreign material in the tissue.[1] Tissue-encapsulation of an implant is an example, as is inflammation around a splinter.[2]

Foreign body granuloma
Perforated IUD.jpg
Transvaginal ultrasonography showing a foreign body granuloma at right as a hypoechoic (dark) area around a perforated intrauterine device. The uterus is at left.
SpecialtyDermatology 

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR). FBR consists of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis. It has also been proposed that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response.[3]

GalleryEdit

  • A foreign-body response to talc (talcosis) due to intravenous drug use. H&E stain.

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  • Foreign body giant cell reaction to nylon suture material

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 Metasyntactic variable, which is released under the 
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